Symptoms of miscarrying one twin, which is known as vanishing twin syndrome, include mild cramping, pain in the pelvic region, vaginal bleeding and a decrease in the level of human...The ACA marketplace still exists, you can still get subsidized insurance if you make below 400 percent of the federal poverty level, and it’s always better to shop around than to l... I think they were 1000 at 5 weeks, with normal being 200-7100. I had very high betas with my singleton pregnancy, possibly due to having had a miscarriage immediately prior. I didn’t even have blood work to confirm this pregnancy, just an ultrasound at 6 weeks so that’s how I found out. HCG LEVELS FOR TWINS AT 5 WEEKS. allgood427. I am exactly 5 weeks pregnant after an IVF cycle. We transferred 2 embryos and our beta today was 7,073. I am super excited about this as our first IVF cycle resulted in a miscarriage. At this point, I just want a happy and healthy baby, but am excited to think that it might be twins?Mar 31, 2021 · Mar 31, 2021 at 11:53 AM. My results for 5 weeks 5 days is at 21385.. I was at 293 on 3 weeks 4 days. Like. N. Novrain. Mar 31, 2021 at 3:37 PM. Mine were at 12000 at 4weeks and then went up to 19000 2 days later when I hit 5 weeks I'm super nervous as they scheduled me in for an early sonogram. Like. Signs of Having Twins at 5 Weeks. Higher-than-normal levels of hCG may indicate that you’re pregnant with multiples, but you’ll need to wait until your ultrasound for 100% certainty. Common early pregnancy symptoms of fatigue, frequent urination, breast tenderness, and food cravings are extra EXTRA — your symptoms are WAY more severe than ...Levels of hCG start to increase after implantation and rise every 39–53 hours in the first few weeks of pregnancy. With twin pregnancies, hCG levels can be 30% to 50% higher than those where ...Melly_sob. Sep 13, 2017 at 4:03 AM. So I had blood drawn at 3 weeks and my hcg was 91 this was through my family Dr. then i finally had my first prenatal visit yesterday and he sent me for blood just to see where I'm at with my hcg and I'm at 531. I'm supposed to be 5+3 today so now I'm worried. waiting for Dr office to call today to tell me ...25–40 weeks. 3,640–117,000 mIU/mL. At around 5 weeks of gestation, the hCG levels for a singleton pregnancy typically range between 18 and 7,340 mIU/ml (milli-International Units per milliliter). The levels of hCG for twins can be higher due to the presence of two embryos. hCG levels at 5 weeks with twins.An hCG level of less than 5 mIU/mL is considered negative for pregnancy, and anything above 25 mIU/mL is considered positive for pregnancy. An hCG level between 6 and 24 …At 3 weeks and 6 days mine were at 42. At 4 weeks, 6 days, they were at 649. At 5 weeks, 6 days, they were at 11,000 something. She says low numbers are fine as long as they are doubling every 2 days. Actually, she said they want them to go up 60%. She also said as long as you're not TOO low, you're numbers themselves don't matter, it's the ...That's a normal range for 5 weeks, I've known people to have hcg around 13,000-20,000 at this time. It just means you have a healthy baby. My hcg at 7 weeks was 134,000 so it would've been around that at 5 weeks.Mar 20, 2021 ... Typically, the hCG level for twins will be around 30-50% higher when compared with a single pregnancy at somewhere about 200 – 1750 mlU/ml. hCG ...Ticker/Siggy Warning: Children and losses mentioned. TTC #1 since 7/2011 ME: 37 DH: 38 SA-12/28/11-normal HSG-1/16/12-possible blocked left tubeA lot of parents want to comprehend hCG levels and a few want to understand hCG levels Twins. Sometimes high hCG levels could be an indicator of a twin pregnancy, but this is not definitive. ... After you have missed your period within the first 4 weeks of a viable pregnancy, your hCG levels will generally double every 48–72 hours. …Updated on October 19, 2022. Medically reviewed by Rachel Gurevich, RN. If your hCG level is high during pregnancy, this could be due to a variety of factors. During pregnancy, your body produces the hormone human …Your hCG levels peak about 8 to 10 weeks into the pregnancy, and then they slow down and level off, according to Brennan Lang, MD, FACOG, an OB-GYN at the Texas Children's Pavilion for Women.hCG levels after week 10. "This means that at the beginning of pregnancy, your hCG number (measured in mIU/ml or IU/l ) might be 2. It'll then move to 4, 8, and 16, and then it really picks up ...Fraternal twins run on the maternal side of your family. If your mother or grand mother or great grandmother had fraternal twins it's likely you could too. Identical twins are random. My hcg levels were at 19,000 at 3 weeks past ovulation. I am also scared I'm having twins. ( maternal grandmother is a twin).At 5.5 weeks I had very high HCG and very low progesterone. I don't remember my HCG but my progesterone was 8. I was put on prometrium supplements and now have a very very healthy almost 2 year old son. It honestly surprised my OB/GYN because she said that with progesterone under 10 she had rarely seen viable pregnancies.Instead, says Dr. Lang, hCG levels usually double in concentration every 29–53 hours during the first several weeks of pregnancy. After about 8 to 10 weeks, hCG levels begin to fall and ...So far I know this: 4 weeks 6 days: 577. 5 weeks 1 day: 923. I hope it's true that numbers don't matter just the growth. Options. CMDR513 member. September 2013. Around 4 weeks- 126. At 5 weeks- 2341 and almost 6 weeks- over 10000.Dec 15, 2022 · HCG levels are measured using MIU/ML, which means milli-international units per millilitre. A singleton pregnancy HCG range typically reaches between 25,700 and 288,000 MIU/ML at the 9 – 12 week mark. A pregnancy with twins may display higher levels than this at the same stage. You can find a HCG levels chart online. Updated on October 19, 2022. Medically reviewed by Rachel Gurevich, RN. If your hCG level is high during pregnancy, this could be due to a variety of factors. During pregnancy, your body produces the hormone human chorionic gonadotropin (hCG). It can be detected via a blood or urine test approximately 12 to 15 days after conception. I had hcg levels of 10,000 at 5+1 and I’ve just seen my baby’s heartbeat at 7+1. All perfectly fine, had a bit of spotting but baby is healthy and measuring well. I hope the same goes for you, or maybe twins! With my last pregnancy, my hcg levels were over 25k at 5w4d. One healthy baby. Apr 11, 2024 · Levels of hCG start to increase after implantation and rise every 39–53 hours in the first few weeks of pregnancy. With twin pregnancies, hCG levels can be 30% to 50% higher than those where ... Summary. hCG is a hormone that plays an important role in pregnancy, and levels can vary widely at this time and between individuals. Outside pregnancy, a high …Mar 18, 2016 ... 8:21 · Go to channel · 5 weeks pregnant with twins signs and symptoms. Twiniversity•452K views · 3:57 · Go to channel · Maternal...4 week HCG Levels. a. aml2204. Mar 28, 2016 at 11:29 AM. Hi there! This month I took Gonal f injections and had 17, 15, 15, 14 and 13 follicles the day of trigger. I just received my first bets and it was 135 12 days past IUI. She said it would probably be around 270 on day 14 and that it was probably twins.The typical hCG level around four weeks of pregnancy is around 140 mIU/ml 5, so a high hCG level can be generally considered to mean you are pregnant. However, there are some very rare medical conditions that can cause high hCG levels. If you get a positive result on a pregnancy test and you haven’t had unprotected sex since your last ...The ratios of AFP levels in twins to those in singletons were from 1.91 to 2.61, the ratios of free-β-hCG levels were from 1.79 to 2.64, and uE 3 levels were from 1.47 to 1.74 during 15–20 weeks of gestation. Xie et al also reported a similar conclusion. Notably, there were significant differences of 2-fold in several gestational weeks ...Sky High hCG. Studies have shown that pregnant people expecting twins or multiples may have higher hCG levels than those experiencing a singleton pregnancy. That said, hCG levels vary from person to person and pregnancy to pregnancy, so hCG levels are not definitive to determine a twin pregnancy. ... After about 12 weeks of pregnancy, …5 weeks exactly today and got my blood work back. 14dpo- 232. 16dpo (4weeks)- 483. 23dpo (5 weeks)-7906 ???? If hcg doubles every 48+ hours the numbers are way higher than I was expecting! We had an IUI and I had 3 viable eggs and I’m super nervous it’s going to be a multiple pregnancy.5 Weeks Pregnant with hCG levels in the 5000 range. n. Nickabee24. Posted 09-11-09. After trying to get pregnant for 14 months, I took a hpt last week and it came back positive. I then went to my ...Oct 25, 2023 · HCG levels rise quickly and exponentially, usually doubling every 2days 3,4 in the first weeks before reaching a steady level (plateau) around week 10; after which time they slowly decline. 4. What should hCG levels be at four weeks of pregnancy? On average, the hCG level at four weeks of pregnancy, is around 140 mIU/ml 5. However, the only way ... "Yesterday's rebound gives the S&P 500 a better chance of confirming last week's breakout above cloud-based resistance [of] 4,155," Stockton said. Jump to The stock market can than...MENLO PARK, Calif., March 03, 2021 (GLOBE NEWSWIRE) -- Twin Ridge Capital Acquisition Corp. (the “Company”), a newly incorporated blank check co... MENLO PARK, Calif., March 03, ...HCG levels: 4 weeks: 93 5 weeks: 667 5.5-6 weeks: 11,797 6.5-7 weeks: 70,977 I also just found out (I did the peek a boo blood test) that I’m having a girl which would def account for the high HCG levels. Wishing you the absolute best. I …Hey ladies, I just asked my doctor for my blood test results from two weeks ago (5 weeks).My levels then were 6836 IU/L, which is apparently on the higher side. Just wondering what everyone else’s levels were around that many weeks?Could it mean …It seems normal to me. Mine was 229,000 at 7 weeks with twins versus 50,000 with a singleton at 7 weeks (that ended in miscarriage though unrelated to hcg) I just had my numbers taken today at 5 weeks 4 days and they were over 40,000. Confirmed twins on ultrasound. At around 7 weeks (give or take a few days since the ultrasound …It reaches its peak by 8-11 weeks of pregnancy and levels off. An hCG level under 5 is considered negative. Between 5 and 25 is considered a low positive and can alert the provider to an abnormal pregnancy (i.e., chemical or ectopic). Over 25 is considered a positive hCG level for pregnancy. This being said, a single hCG level does not provide ...Child-friendly travel destinations in the US, Caribbean and Europe for parents with twins or multiples. Update: Some offers mentioned below are no longer available. View the curren...The only way to confirm this is with a standard ultrasound at around five weeks. What about hCG doubling time with twins? In a twin pregnancy, hCG will most …Mar 31, 2021 at 11:53 AM. My results for 5 weeks 5 days is at 21385.. I was at 293 on 3 weeks 4 days. Like. N. Novrain. Mar 31, 2021 at 3:37 PM. Mine were at 12000 at 4weeks and then went up to 19000 2 days later when I hit 5 weeks I'm super nervous as they scheduled me in for an early sonogram. Like.In general, the HCG level will double every 2-3 days in early pregnancy. 85% of normal pregnancies will have the HCG level double every 72 hours. HCG levels peak at about 8-10 weeks of pregnancy and then decline, remaining at lower levels for the rest of the pregnancy. There is a large variation in a “normal” HCG level for any given time in ...Mar 23, 2016 · 215. Aug 12, 2020. #1. I’m a bit in shock right now. Based on my last period I’m 5w2d today and my HCG was over 26,000! I’m guessing around 24-25 dpo today. I’m going in for an ultrasound tomorrow and scared to death there’s more than one baby in there! With my first baby my HCG at 16 dpo was only 95. Anyone else had HCG levels this ... The typical hCG level around four weeks of pregnancy is around 140 mIU/ml 5, so a high hCG level can be generally considered to mean you are pregnant. However, there are some very rare medical conditions that can cause high hCG levels. If you get a positive result on a pregnancy test and you haven’t had unprotected sex since your last ...Jul 6, 2022 · hCG levels in our blood change during the first trimester, rising rapidly. Nonpregnant women have less than 5 milli-international units per milliliter (mIU/mL). “A normal blood level for hCG on the day a period is due (14 days after ovulation) is 40 to 120 mIU/mL,” Dr. Matthews says. Levels should then double every 48 hours from weeks four ... High HCG Levels at 5 weeks. d. DSW1984. Posted 07-02-15. Hi everyone, This being my first pregnancy, I'm a little worried with my HCG results at 10,000 only 5 weeks into my pregnancy. My doctor has not vocalized much as she can't really say too much until we see what's going on. I'm booked in for a vaginal scan next Tuesday (3 …Signs of Having Twins at 5 Weeks. Higher-than-normal levels of hCG may indicate that you’re pregnant with multiples, but you’ll need to wait until your ultrasound for 100% certainty. Common early pregnancy symptoms of fatigue, frequent urination, breast tenderness, and food cravings are extra EXTRA — your symptoms are WAY more severe than ...Extremely high hcg at 4 weeks. R. Rebekah1978. Feb 2, 2017 at 11:37 AM. I am so scared right now. I thought I was 6 weeks 4 days on 1/31...had u/s that day and baby (only 1) measured 6 weeks exactly. That means my beta drawn 2 weeks prior was 1187 for 4 weeks and 5096 for 4 weeks 2 days.hCG levels rise during the first 6 to 10 weeks of pregnancy then decline slowly during the second and third trimesters. As your pregnancy develops, the increase slows down significantly. Between 1,200 and 6,000 mIU/ml serum, the hCG usually takes about 72-96 hours to double, and above 6,000 mIU/ml, the hCG often takes over four or more days to ...Hcg level at 5 weeks. I just got my Hcg levels for 5 weeks and it was 2060. Just wondering what other mommas had for their 5 week levels. HCG was 2194 @ 4w4d. Going for second beta draw on Monday. Hey, my hcg level was the EXACT same as yours at 4 weeks, 4 days!Mar 12, 2021 · hCG levels rise during the first 6 to 10 weeks of pregnancy then decline slowly during the second and third trimesters. As your pregnancy develops, the increase slows down significantly. Between 1,200 and 6,000 mIU/ml serum, the hCG usually takes about 72-96 hours to double, and above 6,000 mIU/ml, the hCG often takes over four or more days to ... 9,000 - 210,000 µ/L. 16 - 29 weeks (second trimester) 1,400 - 53,000 µ/L. 29 - 41 weeks (third trimester) 940 - 60,000 µ/L. Higher than expected hCG levels may happen if you’re are pregnant with twins and triplets. It may also happen if you have an abnormal growth in your uterus (womb). Falling hCG levels may show a pregnancy loss ...13 - 16 weeks. 9,000 - 210,000 µ/L. 16 - 29 weeks (second trimester) 1,400 - 53,000 µ/L. 29 - 41 weeks (third trimester) 940 - 60,000 µ/L. Higher than expected hCG levels may happen if you’re are pregnant with twins and triplets. It may also happen if you have an abnormal growth in your uterus (womb). Falling hCG levels may show a ...2. phantomrhiannon. • 10 yr. ago. Regarding your last question, yes, your meteoric rise in HCG can absolutely be correlated to your morning sickness. Your body is not used to the hormone levels...some bodies deal with this by getting nauseous. In theory, morning sickness ends with the first trimester, when your body is a bit more adjusted to ...I’m around 9900 hcg, above average for 5 weeks. My sil who just had a baby (and has 5 others, including a set of twins) said she was testing high hcg when pregnant with the twins. There’s no way I’m off on my dates because we abstained from sex leading up to my cycle on purpose, and I have a very regular 26 day cycle which I tracked with ...HCG levels at 5 weeks 3 days. I had a miscarriage last November, i am pregnant again and 5 weeks 5 days today. I had a tiny bit of spotting several days ago so i went in to have my HCG level checked. It was 4000 at 5 weeks 3 days. The doc. had me come back this morning to re-check and make sure the numbers are going up..It is in week three that fertilization occurs so progesterone levels may reach 3 ng/ml everyday or every other day until it reaches the peak at 10-29 ng/ml. In weeks five and six, progesterone levels are at an average of 10-29 ng/ml. This stage is when progesterone starts stimulating blood vessel growth in the uterus to make the placenta …An hCG level of less than 5 mIU/mL is considered negative for pregnancy, and anything above 25 mIU/mL is considered positive for pregnancy. An hCG level between 6 and 24 mIU/mL is considered a grey area, and you’ll likely need to be retested to see if your levels rise to confirm a pregnancy. The hCG hormone is measured in milli-international ...Extremely high hcg at 4 weeks. R. Rebekah1978. Feb 2, 2017 at 11:37 AM. I am so scared right now. I thought I was 6 weeks 4 days on 1/31...had u/s that day and baby (only 1) measured 6 weeks exactly. That means my beta drawn 2 weeks prior was 1187 for 4 weeks and 5096 for 4 weeks 2 days.Jan 5, 2016 · Oyster064. Jan 5, 2016 at 6:37 PM. I was worried that mine were too high at 5.4 weeks. It was 21000 then 2 days later it was 39000. Had ultrasound at 6.5 weeks and saw one baby measuring a little ahead at 7.1 with heartbeat of 143. I was thinking twins or molar pregnancy but everything looked great and only one. Updated on October 19, 2022. Medically reviewed by Rachel Gurevich, RN. If your hCG level is high during pregnancy, this could be due to a variety of factors. During pregnancy, your body produces the hormone human …Twin Bump at 5 Weeks. At 5 weeks of a twin pregnancy, your bump will still not be a true bump, but there will definitely be some bloating. I know that I definitely felt like I was getting a bump, but it was invisible to the rest of the world. If it is a 2nd or 3rd pregnancy, you will likely get bigger faster as well.You cannot diagnose a twin pregnancy just from the hCG. There is no sufficient scientific evidence that with twins there is always a faster-than-usual rise in hCG. Normal hCG values can vary up to 20 times in normal pregnancies. ... Normal amount of serum hCG levels by weeks 3 weeks: 5-50 mIU/cc 4 weeks: 4-426 mIU/cc 5 weeks: 19 …Medically Reviewed. Does High hCG in Pregnancy Mean You’re Having Twins? A higher-than-average level of the hormone early in pregnancy is a possible indicator that you’re carrying...5 weeks exactly today and got my blood work back. 14dpo- 232. 16dpo (4weeks)- 483. 23dpo (5 weeks)-7906 ???? If hcg doubles every 48+ hours the numbers are way higher than I was expecting! We had an IUI and I had 3 viable eggs and I’m super nervous it’s going to be a multiple pregnancy.I think they were 1000 at 5 weeks, with normal being 200-7100. I had very high betas with my singleton pregnancy, possibly due to having had a miscarriage immediately prior. I didn’t even have blood work to confirm this pregnancy, just an ultrasound at 6 …Nov 15, 2022 · Twin Bump at 5 Weeks. At 5 weeks of a twin pregnancy, your bump will still not be a true bump, but there will definitely be some bloating. I know that I definitely felt like I was getting a bump, but it was invisible to the rest of the world. If it is a 2nd or 3rd pregnancy, you will likely get bigger faster as well. What is considered a high hCG level at 5 weeks? hCG levels at 5 weeks should be about 19 to 7,340 mIU/mL. As you can see, it’s a big increase from week 4! ... hcg levels for twins 6 weeks LMP/28DPO has the lowest value of 373 miu/l, while the highest hCG hormone value after 6 weeks gestation is 203398 miu/l for twins babies. …Apr 27, 2022 · This hCG levels chart shows typical hCG levels by week throughout pregnancy Advertisement 3 weeks LMP 5-50 mIU/mL 4 week LMP 5-456 mIU/mL 5 weeks LMP 18-7,340 mIU/mL 6 weeks LMP 1,080-56,500 mIU/mL 9 to 12 weeks LMP 25,700-288,000 mIU/mL 13 to 16 weeks LMP 13,300 to 254,000 mIU/mL 17 to 24 weeks LMP 4,060 to 165,400 mIU/mL 25 to 40 weeks LMP ... In some cases, higher levels of HCG could indicate that a person is pregnant with twins or multiples. However, this is not always the case. Doctors can perform blood tests to screen for HCG levels during the …An hCG level of less than 5 mIU/mL is considered negative for pregnancy, and anything above 25 mIU/mL is considered positive for pregnancy. An hCG level between 6 and 24 …"Yesterday's rebound gives the S&P 500 a better chance of confirming last week's breakout above cloud-based resistance [of] 4,155," Stockton said. Jump to The stock market can than...A new version of the quick-firing Linux keyboard launcher GNOME Do landed last week, bringing with it a "theme" that acts as a whole new desktop interface. Let's check out how it w...Mar 31, 2021 at 11:53 AM. My results for 5 weeks 5 days is at 21385.. I was at 293 on 3 weeks 4 days. Like. N. Novrain. Mar 31, 2021 at 3:37 PM. Mine were at 12000 at 4weeks and then went up to 19000 2 days later when I hit 5 weeks I'm super nervous as they scheduled me in for an early sonogram. Like. Beta hCG levels were taken 12 days after an embryo transfer. What does a high beta hCG mean? A high beta hCG could indicate multiples (twins or triplets), which would be confirmed through an ultrasound. One study found that median hCG levels on Day 13 after a fresh embryo transfer were 329 for women with one baby and 544 for women carrying twins.
Summary. hCG is a hormone that plays an important role in pregnancy, and levels can vary widely at this time and between individuals. Outside pregnancy, a high …. Kathleen mcdaniel chef
They test early, so a low score is likely. But what matters is how HCG levels rise. 85 per cent of viable pregnancies double as they should. 4. Plan your scan. The best way to check on your pregnancy is to have an ultrasound scan. By 6.5 weeks, your HCG levels should be at least 2,000 mIU/ml – and probably higher.In general, the HCG level will double every 2-3 days in early pregnancy. 85% of normal pregnancies will have the HCG level double every 72 hours. HCG levels peak at about 8-10 weeks of pregnancy and then decline, remaining at lower levels for the rest of the pregnancy. There is a large variation in a “normal” HCG level for any given time in ...13–16 weeks from LMP. 13,300–254,00 mIU/mL. 17–24 weeks from LMP. 4,060–165,400 mIU/mL. 25–40 weeks from LMP. 3,640–117,000 mIU/mL. Because every pregnancy is different, it's important ...At 3 weeks and 6 days mine were at 42. At 4 weeks, 6 days, they were at 649. At 5 weeks, 6 days, they were at 11,000 something. She says low numbers are fine as long as they are doubling every 2 days. Actually, she said they want them to go up 60%. She also said as long as you're not TOO low, you're numbers themselves don't matter, …In some cases, higher levels of HCG could indicate that a person is pregnant with twins or multiples. However, this is not always the case. Doctors can perform blood tests to screen for HCG levels during the …<5. 1 week. 5–50. 2 weeks. 50–500. 3 weeks. 100–10,000. 4 weeks ... It doesn't mean that high hCG levels always indicate twins — twins can only be confirmed ...RachelP616. Dec 10, 2014 at 8:54 AM. j. m. muskokamum. Hi-I understand that in the beginning they can be similar, but it is my understanding that multiples drive the hcg up. We did an iui and there were 2 possibly 3 large follicles...I say possibly 3 b/c one day there were 3 similar size and the day we did the iui there were 2.... Congrats to all.May 20, 2022 · Mine at 5w5d was 70,871 with twins. So crazy high. I didn’t check but my first draws were 25,82, and 188 so not ridiculously high to start with around 4 weeks. Your levels seem completely normal so me they double about every 48 hours and yours is slightly above that. Twin hCG Levels . Though it’s not possible to identify a twin pregnancy on hCG levels alone—they vary too widely from person to person to be a definitive marker—hCG levels are generally higher in mamas carrying more than one baby. Compared with singleton pregnancies, hCG and HPL levels were respectively 2.5 and …When you are 5 weeks pregnant with twins, your body has already begun to produce the “pregnancy hormone” Human Chorionic Gonadotropin ( hCG ). Pregnancy tests are designed to detect this hormone, when your HCG level is at a sufficient high. You start producing hCG from the moment the fertilized egg attaches to the uterus.Child-friendly travel destinations in the US, Caribbean and Europe for parents with twins or multiples. Update: Some offers mentioned below are no longer available. View the curren...Dec 6, 2022 · Some people should have their hCG levels tested and analyzed during pregnancy. Learn about a possible risk of low hCG during pregnancy. ... hCG Range (mIU/mL) 3 weeks: 5–72 : 4 weeks: 10–708: ... Aug 29, 2023 ... ... normal hCG levels in singleton pregnancies and how they differ in twin pregnancies. Find out if higher hCG levels always indicate twins and ....
Popular Topics
- Abc news female anchorsLocust fence posts near me
- CcnoOne guy and one horse
- Mulch sale 5 for dollar10 2023Celebration cinema edgewood
- Alachua county wasteLife's treasures thrift store new port richey
- I love sarahii before surgeryLonghorn skull fake
- Koa campgrounds rhode islandGaribaldi tides 2023
- Level f unit 8Effingham jail florence sc